Norepinephrine modulates osteoarthritic chondrocyte metabolism and inflammatory responses

The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism

BACKGROUND Resveratrol is a polyphenolic compound commonly found in the skins of red grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been shown to promote longevity and boost mitochondrial metabolism. We examined the effect of resveratrol on normal and osteoarthritic (OA) human chondrocytes. METHODS Normal and OA chondrocytes were incubated with various conc...

Chondrocyte multiplication in osteoarthritic articular cartilage.

Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism

OBJECTIVES To compare the ability of different cyclodextrin polysulphate (CDPS) derivatives to affect human articular cartilage cell metabolism in vitro. METHODS OA chondrocytes were cultured in alginate and exposed to 5 µg/ml of 2,3,6-tri-O-methyl-β-cyclodextrin (ME-CD), 2,3-di-O-methyl-6-sulphate-β-cyclodextrin (ME-CD-6-S), 2,6-di-O-methyl-3-sulphate-β-cyclodextrin (ME-CD-3-S), (2-carboxyet...

Cytochalasin B Modulates Macrophage-Mediated Inflammatory Responses

The actin cytoskeleton plays an important role in macrophage-mediated inflammatory responses by modulating the activation of Src and subsequently inducing nuclear factor (NF)-κB translocation. In spite of its critical functions, few papers have examined how the actin cytoskeleton can be regulated by the activation of toll-like receptor (TLR). Therefore, in this study, we further characterized t...

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.

induce expression of active proteinases leading to increased matrix degradation. Other fragments increase matrix synthesis and cellular proliferation. Several studies have suggested that type II collagen fragments might influence chondrocyte differentiation in endochondral ossification, and we hypothesise that collagen II fragments might also promote cellular hypertrophy when they are over-prod...